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Koji Ono Selected Research

Hypoxia (Hypoxemia)

12/2019Usefulness of combination with both continuous administration of hypoxic cytotoxin and mild temperature hyperthermia in boron neutron capture therapy in terms of local tumor response and lung metastatic potential.
8/2014Significance of Fractionated Administration of Thalidomide Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.
7/2014Effect of bevacizumab combined with boron neutron capture therapy on local tumor response and lung metastasis.
2/2013Usefulness of Daily Fractionated Administration of Wortmannin Combined With γ-Ray Irradiation in Terms of Local Tumor Response and Lung Metastasis.
11/2011The distribution of vascular endothelial growth factor-producing cells in clinical radiation necrosis of the brain: pathological consideration of their potential roles.
2/2010Influence of manipulating hypoxia in solid tumors on the radiation dose-rate effect in vivo, with reference to that in the quiescent cell population.
8/2009The effect of post-irradiation tumor oxygenation status on recovery from radiation-induced damage in vivo: with reference to that in quiescent cell populations.
5/2009Inhibition of transforming growth factor-beta, hypoxia-inducible factor-1alpha and vascular endothelial growth factor reduced late rectal injury induced by irradiation.
1/2009Significance of manipulating intratumor hypoxia in the effect on lung metastases in radiotherapy, with reference to its effect on the sensitivity of intratumor quiescent cells.
6/2006The usefulness of mild temperature hyperthermia combined with a newly developed hypoxia-oriented 10B conjugate compound, TX-2100, for boron neutron capture therapy.
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Koji Ono Research Topics

Disease

130Neoplasms (Cancer)
11/2023 - 03/2002
24Glioma (Gliomas)
05/2022 - 09/2005
13Glioblastoma (Glioblastoma Multiforme)
05/2022 - 11/2003
13Brain Neoplasms (Brain Tumor)
04/2021 - 07/2006
12Melanoma (Melanoma, Malignant)
12/2019 - 04/2006
12Hyperthermia
12/2019 - 01/2003
12Hypoxia (Hypoxemia)
12/2019 - 10/2004
10Squamous Cell Carcinoma (Epidermoid Carcinoma)
12/2015 - 11/2004
9Head and Neck Neoplasms (Head and Neck Cancer)
02/2024 - 05/2007
8Neoplasm Metastasis (Metastasis)
12/2019 - 10/2007
7Necrosis
05/2022 - 09/2008
7Meningioma (Meningiomas)
01/2022 - 12/2006
7Hepatocellular Carcinoma (Hepatoma)
09/2020 - 01/2007
7Squamous Cell Carcinoma of Head and Neck
01/2016 - 05/2004
5Carcinoma (Carcinomatosis)
11/2022 - 11/2004
5Body Weight (Weight, Body)
01/2020 - 05/2004
4Inflammation (Inflammations)
12/2022 - 07/2014
4Liver Neoplasms (Liver Cancer)
11/2021 - 01/2008
4Clear Cell Sarcoma
12/2020 - 03/2013
4Atrial Fibrillation
09/2013 - 01/2012
4Malignant Mesothelioma
07/2009 - 12/2006
3Neurofibrosarcoma (MPNST)
04/2024 - 12/2010
3Lymphatic Metastasis
04/2018 - 10/2007
3Edema (Dropsy)
07/2014 - 01/2007
2Granuloma
12/2022 - 03/2015
2Residual Neoplasm
11/2022 - 06/2019
2Hypertension (High Blood Pressure)
09/2013 - 01/2012
2Schizophrenia (Dementia Praecox)
10/2009 - 12/2008
2Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung)
08/2009 - 10/2008
1Disease Progression
05/2022
1Radiation Injuries (Radiation Sickness)
05/2022

Drug/Important Bio-Agent (IBA)

41Bromodeoxyuridine (BrdU)IBA
03/2023 - 03/2002
36BoronIBA
11/2023 - 05/2004
17SodiumIBA
03/2023 - 05/2004
9Tirapazamine (SR 4233)IBA
12/2019 - 03/2002
9Cytochalasin BIBA
03/2006 - 01/2003
9SuspensionsIBA
03/2006 - 12/2002
8Liposomes (Liposome)IBA
11/2021 - 10/2004
8Niacinamide (Nicotinamide)FDA LinkGeneric
12/2019 - 10/2004
7EmulsionsIBA
09/2020 - 03/2004
7Boron-10IBA
01/2020 - 05/2008
7mercaptoundecahydrododecaborate (borocaptate sodium)IBA
12/2019 - 12/2002
6Bevacizumab (Avastin)FDA Link
05/2022 - 11/2011
6CarbonIBA
08/2015 - 01/2008
6Boron CompoundsIBA
03/2014 - 05/2004
54-boronophenylalanineIBA
07/2023 - 09/2006
5Therapeutic UsesIBA
11/2020 - 01/2011
5Cytotoxins (Cytolysins)IBA
12/2019 - 08/2005
5WortmanninIBA
06/2019 - 05/2003
5pimonidazoleIBA
10/2017 - 05/2009
4Transferrin (beta 2 Transferrin)IBA
11/2021 - 09/2006
4Phenylalanine (L-Phenylalanine)FDA Link
01/2019 - 07/2009
4Amino AcidsFDA Link
01/2017 - 10/2009
4Proteins (Proteins, Gene)FDA Link
08/2014 - 03/2008
4Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA
07/2014 - 05/2009
4Temozolomide (Temodar)FDA LinkGeneric
12/2011 - 08/2009
3CytokinesIBA
07/2016 - 01/2013
3pitavastatin (itavastatin)FDA Link
04/2015 - 02/2009
3DNA (Deoxyribonucleic Acid)IBA
12/2013 - 03/2002
3Cisplatin (Platino)FDA LinkGeneric
01/2010 - 01/2003
3Monoclonal AntibodiesIBA
08/2009 - 03/2002
3N-acetylcochinol-O-phosphateIBA
01/2007 - 11/2004
3Ethiodized Oil (Ethiodol)FDA Link
11/2004 - 03/2004
2Sorbitol (Yal)FDA Link
11/2023 - 07/2023
2SolutionsIBA
07/2023 - 12/2006
2Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric
11/2021 - 10/2004
2Caffeine (No Doz)FDA LinkGeneric
06/2019 - 03/2013
2GadoliniumIBA
04/2016 - 06/2015
2calcium phosphateIBA
04/2016 - 06/2015
2Gadolinium DTPA (Magnevist)FDA Link
04/2016 - 06/2015
2Oxygen (Dioxygen)IBA
01/2016 - 10/2004
2AntibodiesIBA
08/2015 - 01/2013
2MicellesIBA
06/2015 - 05/2012
2Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA
04/2015 - 01/2012
21-phenyl-3,3-dimethyltriazene (PDT)IBA
03/2015 - 03/2015
2Peptides (Polypeptides)IBA
10/2014 - 03/2014
2NimustineIBA
05/2011 - 08/2010
2MisonidazoleIBA
02/2010 - 03/2006
2Methenamine (Hexamine)IBA
01/2010 - 01/2010
2D-Amino-Acid Oxidase (D-Amino Acid Dehydrogenase)IBA
10/2009 - 12/2008
2Radiation-Sensitizing AgentsIBA
08/2009 - 10/2008
2FluoridesIBA
08/2009 - 09/2008
2TX 2100IBA
06/2006 - 02/2006
23-amino-2-quinoxalinecarbonitrileIBA
02/2006 - 08/2005
1FructoseIBA
07/2023
1Fluorodeoxyglucose F18 (Fludeoxyglucose F 18)FDA Link
12/2022

Therapy/Procedure

101Boron Neutron Capture Therapy
04/2024 - 11/2003
31Radiotherapy
11/2022 - 11/2003
28Therapeutics
05/2022 - 03/2002
9Neutron Capture Therapy
10/2018 - 09/2006
7Drug Therapy (Chemotherapy)
12/2011 - 10/2007
5Intra-Arterial Injections
11/2021 - 12/2011
3Intraperitoneal Injections
12/2019 - 01/2003
3Chemoradiotherapy
06/2014 - 08/2009
2Cyclotrons
01/2021 - 08/2020
2Nuclear Reactors
07/2016 - 04/2016
2Photochemotherapy (Photodynamic Therapy)
03/2015 - 03/2015
2Radiofrequency Ablation
01/2008 - 02/2007
2Craniotomy
09/2005 - 11/2003
1Re-Irradiation
05/2022